Connection | Profiles RNS

Search Result Details

Back to Search Results

This page shows the details of why an item matched the keywords from your search.

Search Results

Moskowitz, Ivan

One or more keywords matched the following properties of Moskowitz, Ivan

Property	Value
keywords	Genetics, Molecular
keywords	Cardiac Rhythm
keywords	Cardiac Arrhythmias
keywords	Congenital Heart Disease
keywords	Genetics
overview	The Moskowitz laboratory is devoted to the genetic, genomic and molecular study of gene regulatory networks. A single overarching theme governs work in the Moskowitz laboratory: that understanding essential gene regulatory networks will unveil the molecular logic governing biological processes, and that understanding network disruption will inform the molecular basis underlying disease. We have recently pioneered approaches to identify non-coding RNAs as markers and modulators of enhancer function (Yang and Nadadur et al, 2017). The Moskowitz laboratory has focused on two areas of cardiac biology: (1) cardiac conduction with respect to cardiac arrhythmias and (2) cardiac development with respect to Congenital Heart Disease (CHD). In cardiac development, we investigate the genetic, genomic and developmental landscape of cardiac morphogenesis. We have identified an essential role for Hedgehog signaling in the cardiac development and congenital heart disease and contributed to a paradigm shift in the understanding of cardiac septation (e.g. Hoffmann et al., 2009; Xie et al., 2012; Zhou et al., 2017). We have recently identified a surprising and novel role for Hedgehog signaling in maintaining cardiac progenitor status and preventing premature differentiation (Rowton et al., 2018). In cardiac rhythm, we investigate the molecular mechanisms underlying the genetic basis of cardiac arrhythmias. We have defined the first molecular networks and linking GWAS loci in cardiac conduction (Arnolds et al, 2012), the first molecular network in Atrial Fibrillation, the most common arrhythmia world-wide (Nadadur et al., 2016) and the functional genomic mechanisms underlying genetic associations (Van den Boogaard et al., 2014).

One or more keywords matched the following items that are connected to Moskowitz, Ivan

Item Type	Name
Concept	Actins
Concept	Age Factors
Concept	Adenosine
Concept	Antigens, Neoplasm
Concept	Aortic Coarctation
Concept	Aortic Valve Stenosis
Concept	Arrhythmias, Cardiac
Concept	Abnormalities, Multiple
Concept	Blood Flow Velocity
Concept	Cardiomyopathy, Hypertrophic
Concept	Cell Communication
Concept	Anti-Arrhythmia Agents
Concept	Anal Canal
Concept	Cleft Lip
Concept	Base Sequence
Concept	Cations, Divalent
Concept	Cell Differentiation
Concept	Cell Movement
Concept	Cell Nucleus
Concept	Atrial Fibrillation
Concept	Chimera
Concept	Bacterial Proteins
Concept	Binding Sites
Concept	Child
Concept	Bradycardia
Concept	Chromosomes, Human, Pair 1
Concept	Cardiomyopathy, Dilated
Concept	Cell Cycle
Concept	Cell Transformation, Neoplastic
Concept	Chick Embryo
Concept	Chromosome Deletion
Concept	Chromosome Mapping
Concept	Genetic Vectors
Concept	Cleft Palate
Concept	Cardiovascular Diseases
Concept	Coronary Artery Disease
Concept	Contractile Proteins
Concept	DNA Nucleotidyltransferases
Concept	DNA-Binding Proteins
Concept	Cysteine Endopeptidases
Concept	Immunosuppressive Agents
Concept	DNA, Bacterial
Concept	Down Syndrome
Concept	Cell Fusion
Concept	Child, Preschool
Concept	DNA, Recombinant
Concept	Ductus Arteriosus, Patent
Concept	Cardiomegaly
Concept	Cilia
Concept	Eye Proteins
Concept	DNA, Superhelical
Concept	Mice, Inbred C3H
Concept	Multienzyme Complexes
Concept	Atrial Natriuretic Factor
Concept	Glycogen Storage Disease
Concept	Fibroblast Growth Factors
Concept	Genetic Complementation Test
Concept	DNA (Cytosine-5-)-Methyltransferases
Concept	Heart Diseases
Concept	Heart Failure
Concept	Heart Septal Defects, Atrial
Concept	Hematopoietic Stem Cells
Concept	Hypertrophy
Concept	Escherichia coli
Concept	Isoenzymes
Concept	Membrane Glycoproteins
Concept	Membrane Proteins
Concept	Microfilament Proteins
Concept	Nerve Tissue Proteins
Concept	Molecular Sequence Data
Concept	Purpura, Thrombocytopenic
Concept	Mice, Inbred C57BL
Concept	Middle Aged
Concept	Repetitive Sequences, Nucleic Acid
Concept	Myocardial Contraction
Concept	Nucleic Acid Conformation
Concept	Ligands
Concept	Pedigree
Concept	Mediastinal Neoplasms
Concept	Fibrosis
Concept	Periodicity
Concept	Pre-Excitation Syndromes
Concept	Procainamide
Concept	Tetralogy of Fallot
Concept	Plasmids
Concept	Poliomyelitis
Concept	Proteins
Concept	Forecasting
Concept	Transcription Factors
Concept	Rec A Recombinases
Concept	Heart Defects, Congenital
Concept	Heart Septal Defects, Ventricular
Concept	Receptors, Cell Surface
Concept	Repressor Proteins
Concept	Risk Factors
Concept	Wolff-Parkinson-White Syndrome
Concept	Cohort Studies
Concept	Regulatory Sequences, Nucleic Acid
Concept	Sodium
Concept	Risk
Concept	RNA
Concept	Time Factors
Concept	Stem Cells
Concept	Trisomy
Concept	Caenorhabditis elegans
Concept	Tamoxifen
Concept	Biomarkers
Concept	Sodium Channels
Concept	Trans-Activators
Concept	Helminth Proteins
Concept	Reverse Transcriptase Polymerase Chain Reaction
Concept	Protein Subunits
Concept	Chromosomes, Artificial, Bacterial
Concept	Ventricular Fibrillation
Concept	Transforming Growth Factor beta
Concept	Extracellular Matrix Proteins
Concept	Vacuolar Proton-Translocating ATPases
Concept	Giant Cells
Concept	Antigens, CD
Concept	Lymphoma
Concept	Mortality
Concept	Chromosomes, Mammalian
Concept	Lower Extremity Deformities, Congenital
Concept	Connexins
Concept	Limb Deformities, Congenital
Concept	Cardiomyopathies
Concept	Myocarditis
Concept	Neural Crest
Concept	RNA-Binding Proteins
Concept	Hypertrophy, Left Ventricular
Concept	Retinal Rod Photoreceptor Cells
Concept	Connexin 43
Concept	Common Variable Immunodeficiency
Concept	Cell Proliferation
Concept	Ventricular Dysfunction
Concept	Disease Progression
Concept	Basic-Leucine Zipper Transcription Factors
Concept	Chemokines, CC
Concept	Cardiomyopathy, Hypertrophic, Familial
Concept	Calcium Signaling
Concept	Xenopus Proteins
Concept	Myosin Heavy Chains
Concept	Single-Cell Analysis
Concept	Peripheral Blood Stem Cell Transplantation
Concept	Intercellular Signaling Peptides and Proteins
Concept	Chromatin Assembly and Disassembly
Concept	Smad4 Protein
Concept	Response Elements
Concept	Cell Cycle Proteins
Concept	Active Transport, Cell Nucleus
Concept	Bone Morphogenetic Proteins
Concept	Small Ubiquitin-Related Modifier Proteins
Concept	Myocytes, Cardiac
Concept	Retinal Dehydrogenase
Concept	Platelet Count
Concept	SUMO-1 Protein
Concept	Progeria
Concept	Postoperative Complications
Concept	Promoter Regions, Genetic
Concept	Receptors, Notch
Concept	Hedgehog Proteins
Concept	Brugada Syndrome
Concept	RNA, Messenger
Concept	Lamin Type A
Concept	Mechanotransduction, Cellular
Concept	HEK293 Cells
Concept	E2F3 Transcription Factor
Concept	GATA4 Transcription Factor
Concept	GATA6 Transcription Factor
Concept	Wnt2 Protein
Concept	Kruppel-Like Transcription Factors
Concept	Inhibitor of Differentiation Protein 2
Concept	Substrate Specificity
Concept	Adaptor Proteins, Signal Transducing
Concept	Insulin-Secreting Cells
Concept	Chemokine CCL4
Concept	NFATC Transcription Factors
Concept	Fibroblast Growth Factor 4
Concept	Fibroblast Growth Factor 8
Concept	Axonemal Dyneins
Concept	Cyclosporine
Concept	Death, Sudden, Cardiac
Concept	Ventricular Outflow Obstruction
Concept	Reproducibility of Results
Concept	Survival Rate
Concept	Integrases
Concept	Troponin T
Concept	Retinal Cone Photoreceptor Cells
Concept	Stroke
Concept	T-Box Domain Proteins
Concept	Homeodomain Proteins
Concept	Cardiac Myosins
Concept	Ubiquitin
Concept	Ventricular Dysfunction, Left
Concept	Gene Dosage
Concept	Cell Lineage
Concept	Macrophage Inflammatory Proteins
Concept	Phosphatidylinositol 3-Kinases
Concept	Caenorhabditis elegans Proteins
Concept	Nuclear Matrix-Associated Proteins
Concept	Electrophysiologic Techniques, Cardiac
Concept	RNA, Untranslated
Concept	Tumor Suppressor Proteins
Concept	Mutant Proteins
Concept	Transcriptome
Concept	AMP-Activated Protein Kinases
Concept	Haploinsufficiency
Concept	Upper Extremity Deformities, Congenital
Concept	Endothelial Cells
Concept	Intracellular Signaling Peptides and Proteins
Concept	Forkhead Transcription Factors
Concept	Induced Pluripotent Stem Cells
Concept	Calcium
Concept	Calcium-Binding Proteins
Concept	Carrier Proteins
Concept	Cell Line
Concept	Cells, Cultured
Concept	Brain Ischemia
Concept	Chromatin
Concept	Conversion Disorder
Concept	Crosses, Genetic
Concept	Cytoskeletal Proteins
Concept	Disease Models, Animal
Concept	Enhancer Elements, Genetic
Concept	Ethylnitrosourea
Concept	Family Health
Concept	Heart Conduction System
Concept	Heart Septal Defects
Concept	Heart Valve Diseases
Concept	Hydrocephalus
Concept	Kinetics
Concept	Models, Biological
Concept	Translocation, Genetic
Concept	Receptors, Platelet-Derived Growth Factor
Concept	Computational Biology
Concept	Genetic Predisposition to Disease
Concept	Potassium Channels, Voltage-Gated
Concept	Databases, Nucleic Acid
Concept	Sarcoplasmic Reticulum Calcium-Transporting ATPases
Concept	Cytoplasmic Dyneins
Academic Article	lin-12 and glp-1 are required zygotically for early embryonic cellular interactions and are regulated by maternal GLP-1 signaling in Caenorhabditis elegans.
Academic Article	Comparison of two murine models of familial hypertrophic cardiomyopathy.
Academic Article	Ventricular arrhythmia vulnerability in cardiomyopathic mice with homozygous mutant Myosin-binding protein C gene.
Academic Article	Cardiac electrophysiological phenotypes in postnatal expression of Nkx2.5 transgenic mice.
Academic Article	The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system.
Academic Article	Electrophysiologic characterization and postnatal development of ventricular pre-excitation in a mouse model of cardiac hypertrophy and Wolff-Parkinson-White syndrome.
Academic Article	Repression of cell-cell fusion by components of the C. elegans vacuolar ATPase complex.
Academic Article	A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development.
Academic Article	Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia.
Academic Article	Characterization of sinoatrial node in four conduction system marker mice.
Academic Article	Complex genomic rearrangement in CCS-LacZ transgenic mice.
Academic Article	The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy.
Academic Article	A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines.
Academic Article	Genome-wide identification of mouse congenital heart disease loci.
Academic Article	A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus.
Academic Article	Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation.
Academic Article	Combinatorial specification of blastomere identity by glp-1-dependent cellular interactions in the nematode Caenorhabditis elegans.
Academic Article	Sarcomere mutations in cardiomyopathy with left ventricular hypertrabeculation.
Academic Article	TBX5 drives Scn5a expression to regulate cardiac conduction system function.
Academic Article	E2F3 plays an essential role in cardiac development and function.
Academic Article	Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected]
Academic Article	Complex interactions between genes controlling trafficking in primary cilia.
Academic Article	Defective sumoylation pathway directs congenital heart disease.
Academic Article	Regulatory variation in a TBX5 enhancer leads to isolated congenital heart disease.
Academic Article	Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy.
Academic Article	Ventricular fibrillation following autologous intramyocardial cell therapy for inherited cardiomyopathy.
Academic Article	sonic hedgehog is required in pulmonary endoderm for atrial septation.
Academic Article	DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis.
Academic Article	Inducible recombination in the cardiac conduction system of minK: CreERT² BAC transgenic mice.
Academic Article	The emerging genetic landscape underlying cardiac conduction system function.
Academic Article	Configuration of DNA strands and mechanism of strand exchange in the Hin invertasome as revealed by analysis of recombinant knots.
Academic Article	Alignment of recombination sites in Hin-mediated site-specific DNA recombination.
Academic Article	The potential to differentiate epidermis is unequally distributed in the AB lineage during early embryonic development in C. elegans.
Academic Article	Hysteria in poliomyelitis.
Academic Article	Giant cell myocarditis in a 12-year-old girl with common variable immunodeficiency.
Academic Article	Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction.
Academic Article	Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis.
Academic Article	Low-dose cyclosporin A therapy in children with refractory immune thrombocytopenic purpura.
Academic Article	Tetralogy of Fallot with congenital aortic valvar stenosis: the tetralogy-truncus interrelationship.
Academic Article	Expression of sumoylation deficient Nkx2.5 mutant in Nkx2.5 haploinsufficient mice leads to congenital heart defects.
Academic Article	Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation.
Academic Article	MATR3 disruption in human and mouse associated with bicuspid aortic valve, aortic coarctation and patent ductus arteriosus.
Academic Article	Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development.
Academic Article	A common genetic variant within SCN10A modulates cardiac SCN5A expression.
Academic Article	The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model.
Academic Article	The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation.
Academic Article	Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm.
Academic Article	Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.
Academic Article	TBX5: A Key Regulator of Heart Development.
Academic Article	Correction: Foxf Genes Integrate Tbx5 and Hedgehog Pathways in the Second Heart Field for Cardiac Septation.
Academic Article	Gata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation.
Academic Article	Chromatin-enriched lncRNAs can act as cell-type specific activators of proximal gene transcription.
Award or Honor Receipt	American Society of Clinical Investigation
Academic Article	Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm.
Academic Article	A promoter interaction map for cardiovascular disease genetics.
Academic Article	Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development.
Academic Article	A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human.
Academic Article	Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics.
Academic Article	Functional Assays to Screen and Dissect Genomic Hits: Doubling Down on the National Investment in Genomic Research.
Academic Article	A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice.
Academic Article	Gata4 regulates hedgehog signaling and Gata6 expression for outflow tract development.
Academic Article	Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis.
Academic Article	Enhancer transcription identifies cis-regulatory elements for photoreceptor cell types.
Academic Article	Chromatin-enriched RNAs mark active and repressive cis-regulation: An analysis of nuclear RNA-seq.
Academic Article	Phosphorylated Lamin A/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria.
Academic Article	Transcriptional Patterning of the Ventricular Cardiac Conduction System.
Academic Article	ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction.
Academic Article	Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation.
Academic Article	Epigenetic and Transcriptional Networks Underlying Atrial Fibrillation.
Academic Article	Chamber-specific transcriptional responses in atrial fibrillation.
Academic Article	Enhancer transcription identifies cis-regulatory elements for photoreceptor cell types.
Academic Article	Control of cardiomyocyte differentiation timing by intercellular signaling pathways.
Academic Article	Author Correction: Identifying genetic factors that contribute to the increased risk of congenital heart defects in infants with Down syndrome.
Academic Article	Identifying genetic factors that contribute to the increased risk of congenital heart defects in infants with Down syndrome.
Academic Article	Identification of direct transcriptional targets of NFATC2 that promote ß cell proliferation.
Academic Article	Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development.
Academic Article	Differential Etv2 threshold requirement for endothelial and erythropoietic development.
Academic Article	Detecting critical transition signals from single-cell transcriptomes to infer lineage-determining transcription factors.
Academic Article	Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages.
Academic Article	Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis.
Academic Article	Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization.
Concept	NAV1.5 Voltage-Gated Sodium Channel
Concept	NAV1.8 Voltage-Gated Sodium Channel
Concept	Zonula Occludens-1 Protein
Concept	RNA, Long Noncoding
Concept	Filamins
Concept	Atrial Remodeling
Grant	Gene Regulatory Networks for Cardiac Morphogenesis
Grant	A Screen for Mouse Cardiovascular Morphogenesis Mutants
Grant	Genetic and Molecular Analysis of Congenital Heart Disease
Grant	Gene Regulatory Non-Coding RNAs in the Human Heart
Grant	Functional Assays to Screen Genomic Hits
Grant	Gene Expression Networks for Human Cardiac Differentiation in Down Syndrome
Grant	Transcriptional Control of Cardiac Conduction System Function by T-box Genes
Grant	Functional Assays to Screen Genomic Hits
Grant	Etiology of Congenital Heart Disease in Down Syndrome
Academic Article	ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment.
Academic Article	Single-cell genomics improves the discovery of risk variants and genes of atrial fibrillation.
Academic Article	The cGAS-STING pathway is dispensable in a mouse model of LMNA-cardiomyopathy despite nuclear envelope rupture.
Academic Article	An Anterior Second Heart Field Enhancer Regulates the Gene Regulatory Network of the Cardiac Outflow Tract.
Grant	High-Throughput Identification of Causal Variants Underlying Cardiac Arrhythmia-Related GWAS Hits
Grant	Gene Regulatory Non-Coding RNAs in the Human Heart
Grant	The Molecular Basis of Cardiac Differentiation Control
Grant	Hedgehog Signaling-Dependent Heterochronic Control of Differentiation Timing in Cardiac Development and the Pathogenesis of Single Ventricle
Grant	Cardiovascular Sciences Training Grant
Academic Article	A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network.
Academic Article	Tbx5 maintains atrial identity in post-natal cardiomyocytes by regulating an atrial-specific enhancer network.

Search Criteria

C
elegans
genetics